Lipotoxic signaling of palmitic acid in endothelial cells
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چکیده
Background: Accumulation of palmitic acid in endothelial cells induces cellular dysfunction and death. Results: Palmitic acid triggers Ca 2+ -dependent autophagy, which results in programmed necrotic death (necroptosis) of endothelial cells. Conclusion: Autophagy promotes lipotoxic signaling of palmitic acid in endothelial cells leading to necroptosis. Significance: Showing a new molecular mechanism of palmitic acid induced cytotoxicity may reveal novel strategies in the treatment of diseases related to lipid overload.
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تاریخ انتشار 2012